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    Premio Toothpaste


    Tested this for over three months. Teeth are brightened and feel cleaner overall. I still have some stains leftover from my braces, and this definitely helped me smoothen the texture of my teeth while keeping plaque and gingivitis at bay.


    Fluoride-free toothpaste from Japan. The first nanohydroxyapatite remineralizing toothpaste. Nano Medical Hydroxyapatite (nano) is a proprietary form of the calcium phosphate compound hydroxyapatite. Biocompatible, and even edible. This toothpaste is designed to collect and remove plaque, fill surface fissures, remineralize subsurface demineralized areas (incipient caries), and relieve tooth sensitivity by filling and coating exposed dentin tubules.

    What is “nano Medical Hydroxyapatite” (nHAP)?
    Nano Medical Hydroxyapatite is a proprietary form of calcium phosphate compound hydroxyapatite, originally developed by Sangi and clinically approved as an anti-caries ingredient in Japan in 1993. Nano is nearly alike in the chemical composition of human teeth and is safe, biocompatible, even edible.

    Suggested Use

    Apply a pea-sized amount to your toothbrush, then brush. Spit and rinse.


    The ingredients of this toothpaste are all approved by the Japanese government. If swallowed in small amounts while brushing, it is not dangerous. Do not swallow, eat, or drink the toothpaste purposefully.

    Water, Dental Grade Dibasic Calcium Phosphate, Concentrated Glycerin, Medical Hydroxyapatite, Macrogol 400, Polyvinylpyrrolidone, B-glycyrrhetinic Acid, Cetylpyridinium Chloride, Xylitol, Sodium SIlicate, Silicic Anhydride, Sodium Lauryl Sulfate, Sodium Carboxymethylcellulose, Flavor, Hydrolyzed Conchiolin Solution, Saccharin Sodium, Trimagnesium Phosphate, Alkyldiaminoethylglycerine Hydrochloride Solution.